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Kategorie: Publications (own)

New publication – baseline measures of SBP, TC, HDL-C, and LDL-C but not the progression of these risk factors are associated with an increased CVD risk

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| Publications (own)

Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, […]

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New position paper from the Section on Secondary Prevention and Cardiac Rehabilitation of the European Society of Cardiology

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| Publications (own)

The benefit of regular physical activity and exercise training for the prevention of cardiovascular and metabolic diseases is undisputed. Many molecular mechanisms mediating exercise effects have been deciphered. Personalised exercise prescription can help patients in achieving their individual greatest benefit from an exercise-based cardiovascular rehabilitation programme. Yet, we still struggle to provide truly personalised exercise […]

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New Review: Exercise training to reduce cardiovascular risk in patients with metabolic syndrome and type 2 diabetes mellitus: How does it work?

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| Publications (own)

Metabolic syndrome (MetS) – a clustering of pathological conditions, including abdominal obesity, hypertension, dysli- pidemia and hyperglycaemia – is closely associated with the development of type 2 diabetes mellitus (T2DM) and a high risk of cardiovascular disease.  A combination of multigenetic predisposition and lifestyle choices accounts for the varying inter-individual risk to develop MetS and […]

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Common Genetic Variation in Relation to Brachial Vascular Dimensions and Flow-Mediated Vasodilation – published in Circulation: Genomic and Precision Medicine

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| Publications (own)

Dörr M, Hamburg NM, Muller C, Smith NL, Gustafsson S, Lehtimaki T, Teumer A, Zeller T, Li X, Lind L, Raitakari OT, Volker U, Blankenberg S, McKnight B, Morris AP, Kahonen M, Lemaitre RN, Wild PS, Nauck M, Volzke H, Munzel T, Mitchell GF, Psaty BM, Lindgren CM, Larson MG, Felix SB, Ingelsson E, Lyytikainen […]

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Our Position Paper on: Exercise training for patients with type 2 diabetes and cardiovascular disease.

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| Publications (own)

Patients with type 2 diabetes mellitus suffer from dysregulation of a plethora of cardiovascular and metabolic functions, including dysglycaemia, dyslipidaemia, arterial hypertension, obesity and a reduced cardiorespiratory fitness. Exercise training has the potential to improve many of these functions, such as insulin sensitivity, lipid profile, vascular reactivity and cardiorespiratory fitness, particularly in type 2 diabetes […]

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New paper in Scandinavian Journal of Medicine and Science in Sports

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| Publications (own)

Peak oxygen uptake (VO2peak) is commonly indexed by total body weight (TBW) to determine cardiopulmonary fitness (CPF). This approach may lead to misinterpretation, particularly in obese subjects. We investigated the normalization of VO2peak by different body composition markers. We analyzed combined data of 3848 subjects (1914 women; 49.7%), aged 20-90, from two independent cohorts of […]

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New paper in JCI

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| Publications (own)

BACKGROUND. Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and function. METHODS. A GWAS meta-analysis of echocardiographic traits was performed, including 46,533 individuals from 30 studies (EchoGen consortium). The analysis included […]

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